The extended Disney Comics Universe is such a large, sprawling corpus of works (some originally not even meant to be in continuity with one another) that the existence of several continuity issues (which may or may not be easy to solve through more or less far-fetched theories) was inevitable. This page is a collection of such problems and possible solutions.
Duckburg Mythos
I - Huey, Dewey and Louie's Age

Impossibly young Huey, Dewey and Louie Duck in 1937, shown in Family Ties.
This problem can, however, be solved with a Broadstrokes attitude, by assuming that a largely similar chain of events where Huey, Dewey and Louie were already four in that scene (and in which they have slightly different motives for asking Donald about her) is the "true" version of events as far as the wider Duckverse is concerned.
II - The Golden Helmet
The Golden Helmet is thrown into the Canadian sea at the end of The Golden Helmet. Various stories brought the mesmerizing artifact back in contradictory ways. In The Lost Charts of Christopher Columbus (written in 1995 but meant to take place at some point prior to 1967), Azure Blue manages to fish the helmet out of the sea and once againt ries to claim America as his, only for the Helmet to turn out to be worthless when an older relic of a pre-Columbus discoverer of America arises.
In Righftul Owners (written in 2010 but taking place around 1990), meanwhile, the Helmet ends up in Scrooge McDuck's private collection, where Huey, Dewey and Louie see it and ask how it got there, referring to the Helmet's disappearance in The Golden Helmet and remarking that Scrooge wasn't even there. While the helmet itself being in Scrooge's collection does not contradict Lost Charts, it is surprising that Huey, Dewey and Louie would ask about it since they had a leading role in the events of Lost Charts. However, considering how often the Ducks are involved in adventures involving brainwashing magic or technology, it is possible Huey, Dewey and Louie got limited amnesia about the events of Charts as a result of some unknown misadventure in-between stories.
Making matters worse is the 1989 story Enjoy the Golden Helmet, a direct sequel to The Golden Helmet that was not taken into account by Don Rosa in the writing of The Lost Charts of Christopher Columbus. Its exact contents are at present unknown to the editors of the wiki, but it is highly unlikely they would square perfectly with the Lost Charts or Rightful Owners versions of events.
Neverland Mythos
I - Peter Pan and Pixie Dust

Peter being sprinkled with Pixie Dust in The Pirate Plot.
There is no satisfying explanation to this mistake; it is most probable, if something must be found, that the magical process undergone just prior to this story by Tinker Bell in The Wishing Well may have temporarily rendered the connection shown in Legend unstable.
I - The Crocodile's Whereabouts in the 1980's

Tick-Tock in A Wolf in Cheap Clothing.
The best way to solve this conundrum is to assume that Dugan in Neverland, in a rare exception to the "release date <=> in-univers date" rule of thumb, actually takes place a few years later than its real-world release date, at the earliest in late 1989.
II - The Crocodile's Missing Ticking
Even in stories where he is unambiguously intended to be the same character, such as Mickey's House of Villains, the Tick-Tock Crocodile is sometimes depicted without his trademark ticking noise. The issue can easily be ignored (by assuming it is merely a quirk of the storytelling and the crocodile was "actually" ticking all along), or, alternately, it can be assumed that the clock, after all these years, does not work right outside of Neverland (as all the examples of its being omitted take place on Earth).
III - Effects of Pixie Dust Removal
In the Disney Fairies series, Neverland pixies like Tinker Bell are shown to require a supply Pixie Dust to fly and work their magic, but otherwise suffer no ill effects from not having any beyond an inability to lift off the ground. By contrast, in Peter Pan: The Legend of Neverland, Tink becomes weak and her glow weakens when Captain Hook strips her of her Pixie Dust (something which eerily resembles the effect of someone saying they don't believe in fairies while in Neverland as seen in Return to Neverland), but on the other hand retains the ability to hover a little.
IV - Timeline

A supposedly 8-year-old Wendy Darling in Tinker Bell.
The issue is best solved, as most do, by ignoring the Wendy connection and holding the Tinker Bell character to be a different, albeit similar, girl who lived decades before her Peter Pan counterpart. If one wishes to preserve a connection, it is possible that the girl would grow up to become the mother of Mary or George Darling, and thus the Peter Pan Wendy's grandmother.