Primarily a musician, Micucci is best known for forming the musical duet (with Riki Lindhome) called Garfunkel and Oates.
Her Disney roles include Stacy in the 2010 Touchstone Pictures film When in Rome, Becky in Cory in The House, Galial in Sofia the First, Stephanie Gooch in the ABC Studios TV show Scrubs, Julie Kane in Motorcity, Buckets in The 7D, and Cute-ling General in Penn Zero: Part-Time Hero. She voices Sara Murphy in Milo Murphy's Law and Daisy in Nature Cat. Most notably, she voices DuckTales 2017’s Webby Vanderquack, and has a few other minor roles in the series, such as Jane.
She has also done other voice acting work, most recently and notably taking over the role of Velma in the Scooby-Doo franchise.