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Matilda McDuck is a female anthropomorphic duck.
Matilda is Scrooge McDuck's younger sister and the seond-born daughter of Fergus McDuck and Downy O'Drake. Always morally upstanding, Matilda was very much the consience of Scrooge, and also helped contain the most destructive tantrums of her sister Hortense.
Matilda left Scotland for America in 1902, following her brother Scrooge to Duckburg, and subsequently traveled around the world with him for several years, before leaving a morally deteriorating Scrooge and going back to Duckburg. When Scrooge finally joined her there, he behaved absolutely horrendously towards her and the rest of their family, prompting both Hortense and Matilda to swear never to speak to Scrooge again.
Some point afterwards, Matilda left Duckburg and went back to Scotland, where she was eventually hired by Donald as a caretaker for Castle McDuck; this is also where Matilda and Scrooge were eventually reunited in 1955. Matilda forgave Scrooge when she understood that he has regretted his behavior toward them and has changed. Scrooge explained that the reason why he didn't make amends with her and Hortense was not out of greed, but out of shame for his behavior. At some point posterior to 1961, she married the professor Ludwig von Drake.
Some accounts would suggest that she was once married to Goosetave Gander, and the two may have even become parents to Oscar Gander, as Oscar is known to be Scrooge's nephew and to bear the name of Gander. They were likely divorced by around 1920, however, as Goosetave had children with another woman, Daphne Duck, around that time.